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For the first time in three decades, researchers believe they have identified a New antibiotic class.
The teams of the McMaster University in Ontario, Canada and the University of Illinois, Chicago, led by researcher Gerry Wright, collaborated in the discovery of lariocidine, which was found that it was effective against drug resistant bacteria.
The results were published this week in Nature magazine.
Lariocidine is a loop peptide, a series of loop -shaped amino acids that attacks bacteria and prevents growing and surviving, according to a McMaster press release.
For the first time in three decades, researchers believe they have identified a new class of antibiotics (not in the photo). (Istock)
Is produced by a type of bacteria Called Paenibacillus, which the researchers recovered from a local backyard floor sample and cultivated in a laboratory for a year.
It was discovered that Paenibacillus produces a new substance that attacks antibiotic resistant bacteria.
“Lariocidine is not susceptible to many of the mechanisms that make cause of diseases Bacteria resistant to available antibiotics, “researchers told Fox News Digital.
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The molecule has a unique structure of an “knotted bond or a pretzel.”
“Lariocidine joins the molecular machine, ribosome, which manufactures all cell proteins, which is one of the most vital processes in cells,” the researchers said.
The finding is significant in the light of the growing antimicrobial resistance, which the World Health Organization has described as a worldwide threat to public health. (Istock)
“It joins a specific site in the ribosome to which none of the known antibiotics joins, and prevents ribosome from protein.”
Another key benefit of lariocidine is that it is not toxic to human cells, researchers said.
The finding is significant in the light of the growing antimicrobial resistance, which the World Health Organization has described as a global public health Threat that kills more than 4.5 million people worldwide every year.
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“The antibiotic resistance crisis that we are currently facing represents a great threat to the way we practice medicine,” researchers told Fox News Digital.
“We need to prevent and treat the infection if we want to continue having access without restrictions on surgeries, hip replacements, Cancer chemotherapyThe treatment of premature babies, etc., consequently, we need new antibiotic medications to do this in the long term. “
“The antibiotic resistance crisis we face currently represents a great threat to how we practice medicine.”
Dr. Marc Siegel, Clinical Professor of Medicine at the Senior Medical Analyst of Nyu Langone Health and Fox News, applauded the discovery.
“Artificial intelligence PROMESAS Improve new pharmacological objectives, even for antibiotics, and in the meantime, McMaster research in Canada has found a new class of antibiotics, “he told Fox News Digital.
Dr. Marc Siegel reiterated that a new class of antibiotics has not emerged in decades, “partly because they are not so profitable, since they only need them when they are sick.” (Istock/Fox News)
“This new type of antibiotic, lariocidine, works when interfering with the synthesis of proteins that many bacteria need to survive.”
Siegel reiterated that a new class of antibiotics has not emerged in decades, “partly because they are not so profitable, since they only need them when they are sick.”
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Dr. Stephen Vogel, family medicine doctor with Plushcare, a virtual health platform with primary care, therapy and Weight control Options said this discovery represents a “promising response” to address infections caused by drug -resistant bacteria.
“Because this microbe can kill bacteria in a way that cannot evolve to evade, due to its protein production system called ribosome, it has the potential to be a lasting and lasting option for a wide variety of mortal Bacterial infections“said the doctor based in North Carolina to Fox News Digital.
“The garden floor may seem worldly, but in fact it is its own universe of microbes, fungi and bacteria, which can lead to key innovations such as the promise that this discovery brings,” said an expert. (Istock)
If this microbe were taken to the market as an antibiotic, it would mean millions of less deaths from bacterial infections every year, according to Vogel.
“The garden floor may seem worldly, but in fact it is its own universe of microbes, fungi and bacteria, which can lead to key innovations such as the promise that this discovery brings,” he added.
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Looking to the future, McMaster researchers will investigate ways to modify and produce the newly discovered molecule for use in Clinical environmentA process that will require significant time and resources.
“This discovery is only the starting point of a long process of developing this molecule in a medication,” researchers told Fox Digital. (Istock)
“This discovery is only the starting point of a long process of developing this molecule in a medication,” researchers told Fox Digital.
“What we have to do below is to try if lariocidine, which can cure animals, is effective for the treatment of a Variety of infections in humans “.
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The researchers added that science is sometimes “fortuitous.”
“You often have to stick a lot of dirt before finding a gem, which lariocidine is certainly. Therefore, financing ‘earth shovel’ is essential to find new gems.”
