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Taking a common free sale analgesic could help certain types to extend.
According to a new study by the University of Cambridge, which found that aspirin could reduce metastacis cancer (propagation) by stimulating the immune systems of the participants.
The findings were published in Nature magazine on March 5.
Aspirin can be linked to a lower risk of colorectal cancer, suggests a new study
In mice models, scientists discovered that a certain protein called ARHGEF1 suppresses T cells, which are immune cells that can identify and attack individual cancer cells that separate from original tumors, according to a press release.
Taking a common free sale analgesic could help prevent certain cancers from spreading, suggests a new study. (Istock)
Arhgef1 “turned on” when T cells were exposed to thromboxan A2 (Txa2), a chemist produced by platelets that helps with blood coagulation. Too txa2 can increase the risk of heart attacks and blows.
That is where aspirin enters: it is already known that it stops the production of TXA2 and avoids coagulation, so it can be recommended to prevent heart events in some people.
“Aspirin or other medications that could go to this route, have the potential to be less expensive than antibody -based therapies.”
“This new investigation found that aspirin prevents cancers from spreading through the decrease in TXA2 and releasing the suppression T cells,” said the press release.
In mice With melanomaThose who received aspirin had less frequent cancer metastases compared to those who did not receive the medication.
Daily aspirin after a heart attack can reduce the risk of future events, the study finds
“It was a moment of ‘Eureka’ when we found that Txa2 was the molecular signal that activates this suppressor effect on T cells,” said the first author Dr. Jie Yang of the Department of Pathology of the University of Cambridge in the statement.
“Before this, we had not been aware of the involvement of our findings to understand the antimethasic activity of aspirin,” he continued.
“Aspirin or other drugs that could point to this route, have the potential to be less expensive than Antibody -based therapiesand therefore more accessible worldwide. “
Aspirin could reduce metastacis cancer (propagation) by stimulating the immune systems of the participants, according to the investigation. (Istock)
Previous studies have suggested that the daily treatment of aspirin is associated with a reduction in the propagation of cancer in humans with the disease and with less cancer mortality in patients without metastasis, said principal researcher Dr. Rahul Roychoudhuri, professor of cancer immunology at the University of Cambridge.
In a random controlled trial, taking 600 milligrams of aspirin daily for an average of 25 months substantially reduced the incidence of cancer in hereditary carriers Colorectal cancer.
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Pashtoon Kasi, MD, medical director of Gastrointestinal Medical Oncology in the city of Hope Orange County in California, reiterated that previous investigations have related the use of aspirins with a reduced risk of cancer, particularly gastrointestinal tract Cancers.
“It has been identified in numerous studies with mixed results to reduce the risk of recurrence and/or improve the results in metastatic cancer patients,” said Kasi, who did not participate in research, Fox News Digital.
“This new study also demonstrates how the aspirin and other inhibitors of this route could be used in new treatments to prevent cancer from getting into or propagation.”
Potential risks
Roychoudhuri, the principal researcher, encouraged caution when applying the findings.
While aspirin is low and widely available, its long -term use is not exempt from “significant risks,” he said, including the bleeding of stomach and hemorrhagic stroke, particularly in older individuals.
While aspirin is low and widely available, its long -term use is not exempt from “significant risks,” the researcher warned. (Istock)
“That is why we emphasize that patients should not start taking aspirin for cancer prevention without their doctor’s specific medical advice,” Fox News Digital told Fox News.
“The risk-benefit calculation varies substantially between people depending on age, concurrent comorbidities and medications,” said the doctor. “Patients interested in aspirin therapy should discuss it with their oncologist or family practitionerwho can evaluate the potential benefits against risks. “
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Kasi pointed out the potential limitations of the study, mainly that the investigation was carried out in mice models instead of humans.
“The study also did not take into account complications that some people who use aspirins regularly experience, such as bleeding or interactions with Other medications“He said.
Experts agree that patients should talk to their doctor to discuss the benefits and health risks associated with regular aspirin use. (Istock)
“However, it is based on the growing body of evidence … and provides mechanistic information on how this effect could occur from an immune perspective.”
Kasi agreed that patients should talk to their doctor to discuss the benefits and health risks associated with the regular use of aspirin.
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“In some cases, aspirin low in doses or other anti -inflammatory medications are already being considered in clinical use, as well as in additional tests, for example, for people born with Lynch syndrome who have a greater predisposition to the development of colorectal cancers, endometrial and others,” he said.
Next steps
Scientists plan to carry out more research, through the additional clinical trial of aspirin, which will recruit more than 10,000 patients with an early, colorectal, gastroesophageal and sinus Prostate cancer Throughout the United Kingdom and India, to determine whether aspirin can stop or delay the recurrence of these types of cancer.
“Patients interested in aspirin therapy should discuss it with their oncologist or family professional, who can evaluate the potential benefits against risks.”
“Our The investigation suggests Aspirin could be more beneficial for patients with early stage cancers who have been treated with healing intention but can house micrometastasis not detected, “Roychoude said.
“However, additional clinical validation is needed before specific recommendations can be made.”
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The investigation received funds from the Medical Research Council, Wellcome Trust and the European Research Council.
The Add-Aspirina clinical trial is funded by Cancer Research UK, the National Institute for Health and Care Research, the Medical Research Council and the Tata Memorial Foundation of India.
